Fast-scan cyclic voltammetry (FSCV) at a carbon-fiber microelectrode (CFM) is a powerful monitoring modality for real-time probing of endogenous neurotransmitters in the brain of behaving animals due to its exquisite spatiotemporal and chemical resolution. Great strides have been made in developing implantable FSCV-based microsystems for high-fidelity wireless sensing of brain neurochemistry, with a particular focus on dopamine signaling.